生物活性

• 描述Sodium tanshinone IIA sulfonate (STS) is one of the derivatives of tanshinone IIA (Tan IIA) which is a main lipophilic constitute of Chinese Materia Medica Salvia miltiorrhiza Bge. (Danshen)^[3].Tan-IIA reduces the production of inflammatory mediators and restores abnormal signaling pathways via regulating the function and activation of immune cells. It can also regulate signal transduction pathways, ie, TLR/NF-κB pathway and MAPKs/NF-κB pathway, thereby tan-IIA has an anti-inflammatory, anticoagulant, antithrombotic and neuroprotective role^[4]. In vivo , echocardiography results showed that Tanshinone IIA could significantly improve heart function. Western Blot result showed that Tanshinone IIA treatment enhanced autophagy and regulated expressions of key autophagy-related molecules, including protein 1 light chain 3 (LC3), p62 and Beclin1. Tanshinone IIA also inhibited apoptosis and regulated expressions of key apoptotic protein, including B cell lymphoma-2 (Bcl-2) and Bcl-2 Associated X Protein (Bax) and cleaved caspase-3 and -7. Further experiments demonstrated that the effects of Tanshinone IIA were mediated through upregulation of AMPK and downregulation of mTOR simultaneously. The mTOR agonist MHY1485 could abrogate the therapeutic effect of Tanshinone IIA in vitro ^[5]. Tanshinone IIA has anti-adipogenic effects on 3T3-L1 cells and zebrafish, and its anti-adipogenic effect on 3T3-L1 cells is largely attributable to the reduced expression and/or phosphorylation levels of C/EBP-α, PPAR-γ, FAS, perilipin A, and STAT-3/5^[6].Tan IIA treatment of high-fat diet fed ApoE-/- mice significantly attenuated NLRP3 inflammasome activation In vivo . Consistently, Tan IIA also potently inhibited oxLDL-induced NLRP3 inflammasome activation in mouse macrophages^[7].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02200978	Childhood Acute Promyelocytic ... more >>Leukemia Collapse <<	Phase 4	Recruiting	September 2022	China, Guangdong ... more >> The First Affiliated Hospital of Sun Yat-Sen University Recruiting Guangzhou, Guangdong, China, 510080 Contact: Xue-Qun Luo, professor       L-xuequn@126.com    Principal Investigator: Xue-Qun Luo, professor Collapse <<
  NCT01452477	Polycystic Ovary Syndrome	Not Applicable	Unknown	July 2014	China, Heilongjiang ... more >> Heilongjiang University of Chinese Medicine Recruiting Harbin, Heilongjiang, China, 150040 Contact: Wenjuan Shen, doctor    +86-045182118464    shenwenjuankx@163.com    Contact: Yuehui Zhang, doctor    +86-045182118464    manbingPCOS@163.com    Principal Investigator: Wenjuan Shen, doctor          China, Jiangsu Huaian Maternal and Child Health Hospital Recruiting Huaian, Jiangsu, China, 223001 Contact: Huiying Xue, Scholar    +8613505238015    haxuehuiying@126.com    Principal Investigator: Huiying Xue, bachlor          Lianyungang Maternal and Child Health Hospital Active, not recruiting Lianyungang, Jiangsu, China, 222000 China, Jiangxi JiangXi University of Traditional Chinese Medicine Completed Nanchang, Jiangxi, China, 330000 Collapse <<
  NCT01637675	Pulmonary Hypertension ... more >> Pulmonary Arterial Hypertension Cardiovascular Diseases Lung Diseases Tanshinone IIA Sulfonate Collapse <<	Phase 2 Phase 3	Unknown	December 2014	China, Guangdong ... more >> The First Affiliated Hospital of Guangzhou Medical University Recruiting Guangzhou, Guangdong, China, 510120 Contact: Jian Wang, MD    +8615013388183    jwang31@jhmi.edu Collapse <<

• 更多
• 参考文献

• [1] Fu J, Huang H, et al. Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis. Eur J Pharmacol. 2007 Jul 30;568(1-3):213-21.

  [2] Wang X, Wei Y, et al. Potential anticancer activity of tanshinone IIA against human breast cancer. Int J Cancer. 2005 Sep 20;116(5):799-807.

  [3] Zhong-Yan Zhou,et al. Sodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics, Biomed Pharmacother. 2019 Oct;118:109362.

  [4] Rui Guo,et al. Drug Des Devel Ther. 2020 Nov 5;14:4735-4748.

  [5] Xuefeng Zhang,et al. Tanshinone IIA protects against heart failure post-myocardial infarction via AMPKs/mTOR-dependent autophagy pathway. Biomed Pharmacother. 2019 Apr;112:108599.

  [6] Yu-Kyoung Park,et al. Anti-Adipogenic Effects on 3T3-L1 Cells and Zebrafish by Tanshinone IIA. Int J Mol Sci. 2017 Sep 27;18(10):2065.

  [7] Jiexia Wen,et al. Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation. Aging (Albany NY). 2020 Nov 16;13(1):910-932.

• 更多

• Collapse